The story of El Shaddai: Ascension of the Metatron takes place in a fantastical interpretation of biblical themes, inspired by the apocryphal Book of Enoch. Enoch is sent by God to capture the angels that have failed in their duties to watch over the human world. These angels, called Grigori, became fascinated with humans and renounced Heaven to live and breed among them. Enoch must traverse their realms, battle their aberrant Nephilim offspring, finally locating the fallen angels and bringing them back into Heaven's fold. As Enoch journeys, he is assisted by the head archangel Lucifel.
El Shaddai: Ascension of the Metatron is a third-person action game that emphasizes platforming and melee combat. The combat system relies on button timing to effect light, heavy, and counterattacks. Enoch has no weapons of his own and must rely on stealing enemies' weapons via counterattacks. These weapons degrade and must be periodically "purified" or discarded for new ones. Combat occurs in arena-like encounters, followed by 3D exploration or 2D platforming. The game's art style is primarily watercolor, with each angel's realm having a distinct theme.
El Shaddai: Ascension of the Metatron was released on the PlayStation 3 on April 28, 2011.