The RoboCop 2 game on the Amiga combines platform levels with a puzzle mode and a first-person shooting gallery. While the puzzle and shooting modes are similar to those on other platforms, the main platform sections feature unique level designs and gameplay mechanics.
All three platform stages present RoboCop with a set goal: destroying the Nuke drug lab, apprehending the criminal Cain, and finally defeating him in his "RoboCop 2" form. On the way to the goals, RoboCop must defeat swarms of henchmen who attack him with guns, mortars, and bazookas, and in the last level, various robotic enemies like flying drones and ED-209s. He can shoot back with a standard gun as well as pick up weapon power-ups in the form of cola cans: three-way shot, scatter shot, and rapid fire.
The large levels feature many elevators, conveyor belts, pipes that leak acid, moving sawblades, crumbling floors, and other deadly traps. Each level consists of several parts, with the later parts accessed through doors or holes in the wall that Robo must punch through. In the first two levels, there will also be hostages crying for help: rescuing ten of them gains an extra life.
After every platform level, a puzzle stage and a shooting gallery follow. In the puzzle stage, RoboCop tries to regain some of his human memories by hitting all red chips on a circuit board. Completing four boards in succession leads to extra lives being awarded.
In the shooting gallery, targets appear in windows and on the street, and a crosshair must be moved to hit them. Accidentally hitting civilians lowers the final score. The second of the two shooting levels takes place at night, with visibility impaired accordingly.
Between levels, digitized images from the film are displayed using the Amiga's HAM graphics mode.