Kane & Lynch Collection is a first-person shooter game where Kane is on his way to execution with prisoner Lynch when their transport is attacked by a group of men. It is revealed later that these attackers are Kane's old associates, who demand the money from their last coup in exchange for his family.
The gameplay revolves around freeing Kane's family after the transport is hit. The camera follows Kane as he moves and can be switched to an over-the-shoulder view while firing. However, Kane will automatically take cover and needs a teammate's adrenaline shot to recover if he is severely wounded.
Most of the game is spent fighting through hordes of police and special forces using various types of weapons, including pistols, assault rifles, and shotguns. Players can also issue commands to Lynch, such as focusing his fire or trading weapons.
The game features an offline co-op mode, where the second player controls Lynch, and an online multiplayer mode called "Fragile Alliance," where players must rob a bank while avoiding being marked as a traitor by their teammates.