Snatcher is set in the futuristic Neo Kobe City, a city of madness and decadence. The year is 2047 (or 2042). Mankind is facing its gravest crisis. A mysterious bio-roid life form has appeared. Its true nature and purpose are unknown. Is it some country's secret weapon, or an alien from another world? They appear in the winter, killing people and taking their place in society. They wear artificial skin and can sweat and even bleed. They are called "Snatchers" because they "snatch" their victims before they take their place.
A new police force has been formed to fight the Snatchers. The player takes control of Gillian Seed, one of the JUNKERs. The gameplay follows a Japanese-style adventure structure. The player uses a menu-driven interface to execute commands, which include moving between locations and interacting with the environment. Every room contains objects that can be examined, leading to text descriptions and comments.
Conversations occupy a large portion of the gameplay, with various topics available and a wealth of information about the game's world and characters. Some parts contain light puzzle-solving elements, though as a rule the game is almost completely devoid of puzzles. During key moments of the narrative, the player will be prompted to participate in intense shooting sequences.
The goal is usually to kill all the enemies that pop out on the screen before they are able to kill Gillian. Some of such sequences are timed, requiring quick action before another event triggers, leading to the protagonist's death. The game follows a linear structure, with each choice leading to multiple endings, making it a unique and engaging experience.