The game takes place in Skeleton Krew 's future world. A baddy named Moribund Kadaver has assumed control of a cryogenics plant near Monstro City. Kadaver is apparently a former mortician who has dabbled in cryogenics ever since he purchased Deadly Enforcement Aggressive Destruction Incorporated, aka DEAD Inc. Now he has the power to unleash mutants called Psykogenix on the population of Monstro City! The Military Ascertainment Department (MAD) has decided to call upon the world's most vicious mercenaries: Skeleton Krew .
Skeleton Krew lets you choose between three members of the deadly organization: Spine, Joint, and Rib. You need to make it through four planets on your way to stop Kadaver's plans.
The areas include Earth, Mars, Venus and finally the Psykogenesis Planet, where you will infiltrate DEAD HQ. A second player can join in for simultaneous play, and you can continue your game via passwords. Skeleton Krew has three difficulty levels.