Missile Command is based on the original arcade game, in which aliens are attacking the Earth. In this version of the game players control two anti-missile silos and have to shoot down the incoming enemy firepower in order to defend several different major cities that have come under siege. Cities consist of six different buildings, which the player has to try and prevent their destruction. If all the buildings are destroyed, the player loses the game.
Gameplay involves using two missile silos, each equipped with fifteen missiles, to shoot down enemy firepower. Players aim their missiles by moving a cursor to the desired location.
The Game Boy Color version of Missile Command was released in 1999 and included color graphics and a rumble feature, which added to the overall gaming experience.