The second in the series of F-15 Strike Eagle II features campaigns in various regions around the world, including Libya, the Persian Gulf, the Middle East, and Vietnam. Players must destroy primary and secondary aerial and ground-based targets on each mission, totaling 250,000 miles of potential action and danger.
The gameplay of F-15 Strike Eagle II allows for a total of 11 camera angles, including internal and external views of the plane, to give players a better understanding of their surroundings. A training mode is also available, which includes options to disable crashes and automate take-off and landing to help new players learn the basics. The game's enemy AI is responsive, but a targeting computer helps players take out enemies before they can do it to them.
The game features two "Director's Modes", which provide an alternative view of the game world by cutting away from the cockpit to highlight special events occurring elsewhere in the game world.