Gameplay involves destroying as many enemies as possible while navigating through levels. You can play through a main mission mode with 15 different missions or opt for non-stop action in Marathon mode. The game also features a level editor and ship editor, allowing players to create their own levels and ships, complete with custom enemy placements and special weapons.
Players can enjoy local multiplayer with up to four players simultaneously or go online to trade ships and levels, compete for high scores, and show off their skills. The game can be played using the Wii remote and Nunchuk controllers, as well as the classic controller. As you progress through the game, you'll unlock TUMIKI Fighters, a game that inspired Blast Works and shares many of its mechanics.