The Umbrella Chronicles features a unique gameplay experience where the camera floats to different areas and players shoot enemies on the screen, picking up ammo, weapons and health kits in progress. In some situations, the controller can also be used as a melee weapon or in timed sequences. Some levels feature multiple paths and there are regular checkpoints. At the end of a level, the player's performance is awarded by stars, which can be exchanged for weapon upgrades. The game supports the Wii Zapper and features cooperative gameplay for up to two players.