Escape The Museum is a hidden object game with elements of the adventure genre. Besides the usual gameplay mechanic of finding objects from a list by clicking on them, the game has adventure portions where the player must collect and use objects to escape from a room. These sections follow simple puzzle patterns.
The player's goal is to find 12 precious artifacts throughout the game and search previous levels for hidden objects. The game keeps track of the player's score based on accuracy, time, object value, and hint usage.
Mini-games include paintings that need to be reassembled like jigsaw puzzles and scales that require shifting weights to reach equilibrium.