Ma Jackson, the owner of Big Mutha Truckers , tells her four sons she is retiring. The new owner of Ma's company will be the son who makes the most money trucking through Hick State County for 60 days.
The objective of Big Mutha Truckers is to transport goods from one city to another, with the goal of making as much money as possible. Players can choose from four different characters: Bobbie-Sue, Cletus, Earl, or Rawkus. Each character has their own truck, and players must navigate through the game's five cities, visiting local stores to buy and sell goods. The player can also visit the local bar to gather tips on where to buy and sell items, as well as complete special missions.