College Hoops 2K6 is a game about college basketball. As the coach, go through Legacy Mode to build respect for your small college and eventually win a championship. You can also play online against players from around the world. The game includes features such as Pre-season, Coach's Clipboard, Midnight Madness, Strip 'n' Rip System, Shot Stick, and V.I.P. System. Another feature is Selection Sunday broadcast shows, where you'll watch your team's placement into the NCAA Tournament and hear commentary on the bracket match-ups.
The gameplay of College Hoops 2K6 focuses on the skills and tactics of basketball. Players can use the Shot Stick to control their shot and make baskets. The game also features a Strip 'n' Rip System, which allows players to strip the ball from opponents and start fast breaks. With V.I.P. System, players can earn rewards and bonuses for performing well in games. The game's online mode allows players to compete against others worldwide.