The main focus of the gameplay is shooting holes in the zombies until they are weak enough for you to fire a vial of your own blood into them, causing an explosion. Weaken enough zombies, fire a blood vial into one, and watch the chain reaction as exploding zombies send your anti-zombie blood onto other zombies.
The game features online multiplayer mode where defeating an opponent would give them your virus, forcing their avatar to appear online like yours. This allows for a global spread of your zombie strain, which can be tracked on a world map.