Duke Nukem 3D is a first-person shooter with a unique twist on its Game.Com version. The gameplay is limited by the console's hardware, restricting movement to forward, backward, strafing left or right, one screen at a time.
The game takes place in three episodes: L.A. Meltdown, Lunar Apocalypse, and Shrapnel City, each with twelve missions based on the original ones from the same name. Players can access these missions by entering specific passwords after dying, which are given to the player upon death. The game features four weapons - boot, pistol, shotgun, and RPG - and four types of enemies: Assault Troops, Pig Cops, Enforcers, and Octobrains. Items such as armor, key cards, med kits, and ammunition can be collected throughout the game.