Backyard Football 2006 is an NFL-licensed American football game geared towards kids with a cartoon style, it is the second Backyard Football game for the GameBoy Advance (GBA). The story revolves around a school football league where students can play against each other. Game modes include pickup games, exhibition matches, season play, practice games and multiplayer.
The gameplay features various options such as three difficulty levels and power-ups to toggle fatigue and turnovers. Teams are divided into two conferences - Frontyard and Backyard - with multiple teams in each conference, grouped into four regions: East, North, South and West. There are 32 NFL teams and 19 exclusive backyard teams available to play with. The game also features different environments and weather options, including sun and rain.
Each player has unique statistics for running, passing, catching, kicking, and block/tackle. Custom characters can be created, adding a personal touch to the gameplay. In Exhibition matches, players take turns selecting a player to build a team, with optional pre- and post-game commentary through an animated sequence. Multiplayer modes support various play styles and strategies.