Destroy All Humans! is a humorous action game with winks to the era of the goofy fifties' sci-fi movies. I, Cryptosporidium 137 of the Furon Empire, happened upon your planet on the way back from destroying the martians. Due to some experiments with atomic weaponry, we lack genitalia and the quality of our clones has degraded. Since you pathetic humans all carry Furon DNA in your genetic code, I have been instructed to collect fresh samples. Survival is not an option, but you should be honoured to support the legacy of the Furon Empire!
Destroy All Humans! features a third-person shooter gameplay style. Crypto can hypnotize and scan people, and lift objects using psychokinesis. He can also control humans using the Hypno Blast to impose his commands. Extracted DNA can be exchanged in your mothership for new weapons and ability upgrades. Furon weaponry includes a Zap-o-Matic, disintegrator ray, abducto beam, quantum deconstructor and even the famous anal probe. Not to be overpowered, you have to disguise yourself using the Holobob.
Gameplay involves completing missions, collecting DNA samples, or killing humans to meet specific targets. The game features different alert levels, similar to those found in Grand Theft Auto games, and if you are not careful, you will be hunted down by the police, military or the government. You can also use your flying saucer to abduct humans or animals, cause havoc or face bigger threats.
Destroy All Humans! was released on June 21, 2005, for the Xbox console.