The story revolves around Tak, who must rescue his fellow villagers from the evil shaman Tlaloc. Tlaloc has prophesied to steal the Moon Stones, aiming to cause the fall of the Moon Juju. With Tlaloc's evil plan unfolding, Lok's apprentice, Tak, is left behind as all the villagers are turned into sheep.
The gameplay in Tak and the Power of Juju features side-scrolling action. Players must navigate through eight worlds, each with multiple levels to complete. Tak starts off with a blowgun, which he can upgrade to a club during his adventure. The game also includes swimming and flying levels to add some variety to the gameplay.