Darksiders III is an action role-playing game where the player returns to an apocalyptic Earth as Fury, one of the Four Horsemen of the Apocalypse, in her quest to hunt down and dispose of the Seven Deadly Sins. From a behind view, she fights enemies using her whip and Hollow weapons acquired throughout the game. The combat is slower and more methodical than before, focusing on Fury's dodge and counters. The player can choose between eliminating enemies spread throughout the map or simply passing them by.
The leveling system and buffs are a central part of the gameplay. Enemies drop Souls when killed, which can be recovered by hitting them. These Souls are used as currency but also an integral part of the leveling system. Players can trade them for points to upgrade health, damage, or arcane damage at a checkpoint.
Weapons can be given perks by equipping them with Runes, which can be upgraded upon talking to Ulthane and providing him with materials collected during exploration.
The game's difficulty is scaled every time Fury defeats one of the Sins, and all enemies in the game are buffed to match her level.