Darksiders III is an action role-playing game where the player returns to an apocalyptic Earth, assuming the role of Fury, one of the Four Horsemen of the Apocalypse, in her quest to hunt down and dispose of the Seven Deadly Sins. From a behind view, she fights enemies using her whip and Hollow weapons acquired throughout the game. The combat is slower and more methodical, focusing on Fury's dodge and counters, with varied ground and aerial moves. The player can choose between eliminating enemies spread throughout the map or simply passing them.
The leveling system and buffs are a central part of the gameplay. Enemies drop Souls when killed, which can be recovered by hitting and placed near the point of the last death. These Souls serve as a form of currency and are used to upgrade Fury's abilities. The player can trade them for points with Vulgrim at checkpoints.
Weapons can be given perks by equipping them with Runes, which can be upgraded with materials collected from exploring different areas in the game.
The game's difficulty increases every time Fury defeats one of the Sins, and all enemies are buffed to match her level.