The gameplay features three categories of attacks: Light attacks (acrobatic kicks and punches using her pom-poms), Heavy attacks (furious chainsaw slashes), and Super attacks (used for killing zombies and saving classmates, filling up Juliet's star meter). Juliet also uses the disembodied head of her boyfriend, Nick, as a projectile device. The player can possess Nick's zombie body while assisting Juliet, and completing challenges upgrades Juliet's skills and abilities.
As players progress through the game, they earn medals (gold or platinum) by killing zombies, which are used to upgrade Juliet's stats and unlock new signature moves at Chop2Shop.zom. The game features a unique mechanic where massacred zombies explode in light bursts instead of blood, and depending on conditions, two endings are displayed.