The story begins with Edward 'Stubbs' Stubblefield, a traveling salesman who gets killed in the 1930s. Fast forward to 1959, when millionaire Andrew Monday builds his dream city, Punchbowl Pennsylvania, on top of Stubbs' grave. You control Stubbs as he navigates through the city's citizens, including police officers, militiamen, scientists, and a deadly barbershop quartet.
As you progress through the game, you'll be aided by hordes of zombies that you can create by killing humans. You'll also unlock special powers for Stubbs, such as using his flatulence to stun enemies, throwing his pancreas as an explosive grenade, and detaching his head to take control of enemy humans.