The story begins with Edward 'Stubbs' Stubblefield , a traveling salesman from the 1930s, who gets himself killed. Fast forward to 1959, where the world's richest man, Andrew Monday, has built his dream city, Punchbowl Pennsylvania, on top of Stubbs' grave. Stubbs will have to claw through all of Punchbowl's citizens, including the local police department, crazy militiamen, nerdy scientists, and a deadly barbershop quartet.
Luckily, Stubbs has some help. Every human that he kills comes back as a zombie and joins Stubbs in his quest for brains. Stubbs also learns a series of special body powers. He can use his unholy flatulence to stun enemies, he can throw his pancreas as an exploding zombie grenade, and he can detach his own head and bowl it into enemies. Stubbs' most powerful ability is that he can detach his hand and use it as a scout, climbing up walls and the ceiling, and then use it to take control of enemy humans and their weapons.