Destructo 2 is a simple color-matching puzzle game similar to Mr. Driller. The main objective is to guide a cartoon character moving through an ascending pile of multicolored tiles, pushing the available blocks to create clusters of the same color. Groups of four or more tiles of matching colors can be removed by punching one of the connected blocks, with the vacant space being occupied by the falling stacks on top.
The game becomes increasingly challenging as the tiles accumulate on the screen and the water level at the bottom rises. The character's health meter is displayed below the gamefield, decreasing when suffering injuries or drowning. Power-ups and other items can be found inside containers that randomly appear on the pile, which have to be broken open with three punches to reveal their contents.
The blue items give bonus points, eliminate all the tiles of a particular color, lower the water level, and help in other ways. The red items do the opposite and must be avoided. As the player progresses through the game, the blocks become more difficult to remove, requiring quick reflexes to progress.