Detective Mouse is set in a fictional world where the player takes on the role of a mouse detective tasked with solving crimes. The game features a storyline inspired by a Dingo Pictures animated film, Ein Fall für die Mäusepolizei , which adds to the game's theme and atmosphere.
The gameplay in Detective Mouse is action-packed, as players navigate through levels, solving puzzles and avoiding obstacles. The game features six different sliding picture puzzles with varying difficulty options, as well as a coloring book mode for those who prefer a more relaxing experience.