de Blob 2's story starts off with the central location, Prisma City, and its upcoming general election following the events of the first game. A mysterious priest called Papa Blanc deviously plans to rig the elections in order to gain power. Once successful, it is revealed that he is in fact working for the evil corporation from previous games, The INKT Corporation. With this success, he begins to drain colour from the cities as well as the inhabitants, in order to uniform the world in a total lack of colour and uniqueness. It is up to our hero Blob and the members of the Colour Underground to restore the city to its vibrant former glory. Blob frees the lands one by one, rescuing and reuniting friends along the way. It is his mission to restore the world to colour, free the population, and stop the mysterious INKT Corporation once again.
Compared to de Blob 2 , previous titles have more types of enemies, power-ups, and improved graphics in higher resolutions. Blob's new dash attack allows for faster progress but at a cost to paint points. Upgrades can be purchased with inspiration points, including better defence and increased paint capacity. The game also features various power-ups, such as transforming Blob into a wrecking ball or a black hole, which provide unique abilities to overcome obstacles.