De Blob 2 's story begins with the city of Prisma City facing an upcoming general election, which becomes a battleground for the sinister plans of Papa Blanc and his evil corporation, The INKT Corporation. As they drain colour from the cities and its inhabitants, it's up to our hero Blob and the Colour Underground to restore the city to its vibrant former glory.
Gameplay in De Blob 2 has been revamped, moving away from Wii motion controls and embracing a more standardised console control scheme. The colour-changing mechanics from the first game return, allowing Blob to absorb paint colours and create a world of vibrant hues. A competitive multiplayer mode allows up to two players to compete in painting the world quickest, while co-op play with Pinky provides additional assistance.
Additional features include more types of enemies, power-ups, and increased resolutions compared to the previous title. Blob 's new dash attack can kill enemies and break through obstacles, but at the cost of paint points. Upgrades can be purchased with inspiration points, granting better defence, carrying more paint, or transforming Blob into a wrecking ball or hazmat suite. The game also introduces 2D platform challenges within buildings, requiring completion before they're fully taken.