Rock Band 3 is the third game in the main Rock Band series, featuring new additions to the original game. Players form a band of up to seven players and perform a song together using guitar, bass, drums, vocals (solo or harmonies), and keyboard. By working together, players can maximise their scores. Each player can fill a power bar by performing special sets of notes. When they have enough of these, they can activate "Overdrive", which adds a x2 multiplier for each player that has Overdrive activated simultaneously.
Vocal harmonies, first introduced in The Beatles: Rock Band , are carried over into the main series for the first time. Up to three players can perform on the microphone, with one player performing the lead, and the remaining players performing backing vocals. By keeping in harmony with each other, players can earn double or triple score, depending on how many players can keep up. The game also introduces a new style of play for each instrument, "Pro Mode". Pro Mode is more accurate to actual instruments.
The Career Mode has been revised for this game. Rather than grinding to earn money to unlock new items, the game is based around Achievement-like goals. Each goal you unlock earns you more fans for your band, and often unlocks new items of clothing or instruments. All songs are initially unlocked, while those looking for a deeper experience can tackle the "Road Challenge" mode.