Escape Dead Island is a spin-off from the main Dead Island series, outside of the main canon, and it is done by a different developer. Unlike the main series, it is played from a third-person perspective. The visuals are changed to a cel shaded look with action words that appear on the screen similar to comic books. In this survival action game, the player controls Cliff Calo who travels with two friends to the Banoi archipelago, mainly the Narapela island, to investigate reports about strange events there. His main goal is to gather evidence by taking pictures with his camera, proving the Geopharm corporation is active on the islands. The game's tutorial is set slightly before the rest of the game where the player controls the operative Kilo Two who infiltrates a Geopharm facility to discover the identity of the mole, two days before the outbreak. Xian Mei, from the main game series, also appears as a character in the game.
The gameplay is linear, with many locations blocked off until a specific point in the story. Many familiar elements return, such as the ravaged tropical setting with infected humans wandering about. Calo's mental state causes him sometimes to quickly move between locations or shows strange events. As an action game, Calo is able to attack with melee weapons along with minor gunplay with a pistol and a shotgun due to scarce ammunition. Stealth is necessary to sneak up and stealth kill groups of enemies, as they react to movement and sound. Infected can be dodged, crouched, sprinted past, kicked aside, or targeted for attack.
Like the original games, stamina drains after attacks, requiring a few seconds to fill up again. Unlike the originals, weapons cannot be customized, and they are provided at certain points in the game. There are no RPG elements or an upgradable character system. Calo can use a rope and a grappling hook to move around, and keycards often need to be found to open doors.