The story of Madcatz Blaster revolves around an evil scientist who has taken over a secret base. The player must infiltrate the base, avoiding obstacles and enemies along the way, to stop the scientist's nefarious plans.
The gameplay in Madcatz Blaster is focused on shooting and combat. Players use the light gun controller to aim and fire at targets, with an emphasis on quick reflexes and accuracy. The game features various levels set in different locations, including a laboratory and a futuristic control room.