Jungle Strike is set after Operation Desert Strike , where Ibn Kilbaba, son of Kilbaba Sr., threatens to destroy America. After his father's death, Kilbaba seeks revenge for those who killed him and teams up with Carlos Ortega, a notorious drug lord. The player must follow their trail in the jungles of South America.
The gameplay involves battling Ibn Kilbaba's private army using various vehicles and weapons, including Hellfire missiles, Hydra rockets, and chain guns. The player can also use watercraft to launch mines at enemy ships or pull off drive-bys with guns on the side. With the Comanche, numerous other vehicles, and destructive weapons at their disposal, players must take out the enemy to save America.