The player takes on the role of either Zeke or Julia in Zombies Ate My Neighbors , a game where they must fight vampires, mummies, zombies, and other creatures to rescue their neighbors from destruction. The goal is to complete 50+ levels, including secret ones, and save all the neighbors who have survived.
The gameplay involves using different weapons such as bazookas or water guns to kill regular enemies and bosses at the end of each level. The levels take place in a variety of settings, from malls and grocery stores to beaches and football fields. With over 50 levels to complete, the player must navigate through these environments while avoiding hordes of monsters.