Lester the Unlikely follows the story of Lester, who falls asleep on a pallet while reading his favorite comic in Seaport City's loading docks. He wakes up to find himself stranded on a ship that's been hijacked by pirates and scuttled at sea.
The ship eventually reaches its first port of call, but disaster strikes when the pirates are replaced by giant seagulls. Lester is forced to navigate through various obstacles, including panthers, in order to survive. With the spirits of the underworld also lurking in the background, Lester's real adventure has begun.