Family Guy: Back To The Multiverse is an action-adventure game based on the TV animation series, specifically a sequel to the episode "Road to the Multiverse" from the eighth season. Players control Brian and Stewie Griffin as they try to prevent Stewie's evil half-brother Bertram from creating an army strong enough to kill Stewie. Players go through seven different universes with each having a unique ruler, ranging from the Amish to giant chickens.
The game is played as a third-person shooter, where Stewie uses a laser gun and a flamethrower, while Brian wields a shotgun and a pistol. Some situations require a specific character's weapon to solve small environment puzzles and progress. Players can collect cash to upgrade their characters' abilities at the multiverse store, unlocking improved health and ammo capacity.