The game starts in a club house in Alderney, in the Western part of the city where Niko only got access late in the game. The entire city is available at once. Contrary to the first game and in the spirit of the biker gang Johnny's in, there is much more focus on team work with the other members. Their health bars are also shown on the screen. When a member dies in action, he needs to be replaced by a less experienced youngster, making it harder to progress and encouraging the player to look after his peers. There are also strict rules in the gang, especially when riding around in a set formation is required. Members can be called to provide weapons and stealing other vehicles is less encouraged. Johnny starts on a custom bike that is virtually indestructible, though it can be replaced. Most of the new vehicles are bikes, but there are also a few new trucks and vans.
The clubhouse offers new minigames such as arm wrestling, pool and card games. There are new sites on the internet, new TV shows and three new radio stations with a focus on hard rock. Next to the regular storyline there are challenges based on racing or gang wars. The new weapons are a grenade launcher, an assault shotgun, a pool cue, a pipe bomb and an automatic 9mm.