The story revolves around Ms. Pac-Man's attempts to clear four challenging mazes filled with dots and bouncing fruit while avoiding Inky, Blinky, Pinky, and Sue, each with their unique personalities and tactics. The player must navigate the maze, eating dots and avoiding ghosts, while also collecting Energizers to turn the tables on her pursuers.
The gameplay involves surviving rounds of challenging maze navigation, where Ms. Pac-Man can eat the ghosts for bonus points during the Energizer power-up phase. However, this power only lasts for a limited time, as the ghost's eyes regenerate and resume their pursuit.