Call of Juarez: Gunslinger is the fourth main game in the shooter series, returning to the Old West setting of Call of Juarez: Bound in Blood. The player takes on the role of Silas Greaves, a bounty hunter, and plays through three game modes: Story, Arcade, and Duel. In Arcade mode, players travel through locations, defeating enemies and aiming for high scores by maintaining combo sequences.
The story follows Greaves as he completes missions in 1910, which are presented as cut-scenes with drawn still images and voice-overs. These scenes serve as flashbacks to the gameplay sequences, but sometimes the player's choices affect the environment, removing or introducing new elements. Players can also search for Nuggets of Truth, which provide historical context to Greaves' tales.
The gameplay revolves around completing objectives and shooting down enemies, with access to various guns and experience points that allow players to upgrade their skills. The game features three skill categories: Gunslinger, Ranger, and Trapper, each with upgrades such as faster aiming and reloading. Players must use quick reflexes in gunfighter duels and dodge bullets through time events. Lethal shots can only be avoided when the Sense of Death meter is full.