Tower of Babel tells the story of three robots - the Zapper, Pusher, and Grabber - who were sent to the planet of the Shinerians but are now trying to return home. In their quest, they must climb a high tower filled with traps and negotiate through the dangers that lie within. The robots have eliminated the Shinerian race, but can only contact their masters by reaching the top.
The gameplay revolves around each robot's unique skills and abilities, which must be combined to progress through the levels. Each section presents its own challenge, such as collecting energy pods or destroying mines and bombs. The game also features creatures that fill the tower, which must either be avoided or used to the player's advantage.