Bazooka Bill is on a mission to rescue General MacArthur who has been kidnapped by a nasty revolutionary faction, and to get to him, he must get through five levels of shooting soldiers and choppers that drop bombs on him. He deals with them by mainly using his fists, although he can pick up a variety of weapons such as knives, machine guns, flamethrowers, and, of course, bazookas.
Gameplay is all about strategy and quick thinking as Bill must use his wits to navigate through the levels, avoiding danger at every turn. The player must also manage Bill's limited ammunition supply, choosing when to use each weapon effectively. Completing each level requires finding the right position to escape, adding an extra layer of challenge to the game.