Green Lantern: Rise of the Manhunters is set in a universe inspired by the DC comic, specifically tied to the 2011 movie adaptation. The story follows Hal Jordan as he navigates the Green Lantern Corps and battles against an ancient threat. Thousands of years ago, powerful beings known as the Guardians created androids called the Manhunters, designed to maintain order throughout the galaxy. However, these androids became corrupted, bringing destruction and chaos instead.
The gameplay revolves around side-scrolling action, with a focus on combat using various tools provided by the Green Lantern ring. Players can wield it as a ranged weapon or use it in melee fights as a sword or hammer to defeat enemies. Some levels are played from behind, offering a different perspective on the game world.