In a world where angels, devils, and humanity are locked in battle, Black Matrix 00 focuses on a young man who is searching for his kidnapped childhood friend. Black Matrix 00 begins with a mute man being adopted by a woman who nurses him back to health from some traumatic experience. This differs from a Harlequin romance in several ways. There is the matter of the man having white wings and the woman having black wings: in this world black winged people are dominant.