Time Crisis 4 is the fourth main game in the series and was once again ported from the arcade version. In the original arcade mode, the plot tells about Giorgio Bruno and Evan Bernard, part of the taskforce V.S.S.E., who investigate a secret weapon that is smuggled by a terrorist organization known as W.O.L.F. The gameplay in Time Crisis 4 involves timed sections where both offensive and defensive actions need to be taken. The game can be played with two players simultaneously, and it is possible to switch between the different available weapons, just like in previous titles.
New to the console version is the inclusion of the Complete Mission mode, where the player controls captain William Rush, who has the same mission as the V.S.S.E. operatives. This mode introduces free-roaming environments, collecting items, investigating locations, and taking over turrets. There are also Crisis missions and shooting gallery mini-games.
The game comes with a Guncon 3 light gun controller, which uses infrared emitters instead of the cathode ray timing of previous controllers. To assist with free-roaming segments, two analog sticks are fitted to the console version.
Time Crisis 4 was released for the PlayStation 3 on January 1st, 2010.