Cabela's Big Game Hunter 2010 takes you to various hunting locales, tasking you with hunting down the biggest kills for the most points, including deer, rams, and even bears. The game's tracking system allows you to find your way through levels using the Hunter's Sense power, which also helps you determine where to make a kill shot. You are graded on each individual kill/challenge, and rewarded with medals based on your performance in the 4-to-10 challenges per level. In addition, there are shooting galleries available for playing to achieve high scores.
The gameplay is straightforward, with the primary objective being to hunt and collect points throughout the various levels. The game features a range of animals to hunt, each with its own unique characteristics and behaviors.