The gameplay in BioShock Infinite builds upon familiar styles and mechanics from previous games in the series. Vigors grant superpowers, such as summoning crows or charming enemies, while possession allows Booker to take control of humans or machines to aid him. The game also features a variety of upgradeable gear, including pistols, shotguns, rifles, and the unique Sky Hook melee weapon. Salt is needed to execute vigors, and health can be extended with infusions. Players can find items by looting barrels and enemies, and upgrades are available at vending machines.
The game also features a unique skylining system, allowing Booker to attach himself to skylines using the Sky Hook and quickly move around the world. This mechanic provides an alternative way to navigate the environment and gain a combat edge.