Saints Row IV begins with the protagonist, now President of the USA, being kidnapped by aliens who attack the White House. The story continues from Saints Row: The Third , where the Saints gang extended their reach and the protagonist became the President of the USA. After a press conference, disaster happens: aliens attack the White House, kidnap the Saints and trap each in their personal, indefinitely looping nightmare. Fortunately Kinzie, the group's hacker, rescues the protagonist and together they flee into a space ship with the goal to rescue the rest of the gang. Saints Row IV continues the course of its predecessor into over-the-top action and humour. The twist of this game is that the protagonist receives super powers within the simulation, e.g. super jump, fast running or telekinesis, which help with moving fast and killing aliens which replace cops as law enforcement. The gameplay features various side activities which can be activated in certain points of the game world. The game switches to the mini game after completing it, and the player is rated with either bronze, silver or gold medal depending on the performance. While some of the games are known from the predecessors, e.g. fraud or tank mayhem, the majority are new and are designed around the superpowers.
The main storyline features varied missions which mostly involve moving to a point and killing everything in sight, but also various sequences parodying other genres like side-scrolling brawlers or top-down shooters. Additionally there are other side activities like collecting audio diaries or destroying the aliens' infrastructure points.
Progressing in the game gives rewards: experience points (used to unlock personal upgrades like better damage resistance or more damage with certain weapons) and cache (used to purchase weapons, ammo and weapon upgrades) is rewarded for all actions in the game, but of course finishing missions and activities is most profitable.
New super powers are automatically unlocked during the storyline, but they also have upgrades like sliding through the air after a super jump or more damage for blasts. These upgrades require another currency: small glowing balls which are all over the city and need to be collected.
Multiplayer is either playing co-op during the campaign (the second player basically replaces the homie) or starting one of two competitive activities.