Gameplay in Guitar Hero Live revolves around playing notes as they appear on screen, with different colors and notes corresponding to different rhythms and chords. Players can perform solo hits, which allow them to take control of a song's lead vocals or guitar parts for short periods of time.
One of the unique features of Guitar Hero Live is its use of crowdsourced music content, where players can download new songs from a variety of sources and add them to their game library. The game also includes a mode called "Guitar Hero Live TV," which lets players compete against other players in real-time.