Corpse Killer is a full-motion-video (FMV) shoot-'em up. It seems the evil genius Dr. Hellman has found a way to raise the dead and created an island of zombies. The player is an elite special forces soldier who has been parachuted onto the island; it is up to them to shoot their way through the undead hordes and stop Dr. Hellman.
The gameplay involves shooting zombies from a first-person perspective, with various enemies popping up in front of a video background. Players can use either a mouse cursor on-screen or a light gun to defeat the undead.
The Sega 32X version of Corpse Killer offers some extra features compared to other platforms, including additional enemy footage and power-ups.