The story begins with the release of the Clone-a-Matic, a device that solves all of Dexter's problems. With it, he can create multiple clones of himself and complete his tasks more efficiently. However, things quickly take a turn for the worse when his sister activates the machine, causing a swarm of miniature Dee-Dees to flood his laboratory.
In Dexter's Laboratory Disaster Strikes , players must navigate through their laboratory, collecting miniature clones and returning them to the Clone-a-Matic for recombination. Along the way, they'll need to avoid destruction from their former robots and hazardous environmental obstacles.