The object of King of the Monsters 2 is similar to its predecessor. Choose from three monsters which include a large lizard, a large robotic ape, and a huge mutant human. Then walk through each city, making sure to destroy everything in site, including planes, buildings, and other creatures. When smashed, some buildings reveal power-ups that make your character more powerful. At the end of each city, you go head-to-head with the boss creature. There are small stages in between where you fight a second monster for bonus points, or you fall from the sky and land underwater where you try to collect points and power-ups while falling.
The gameplay is fast-paced and action-packed, requiring quick reflexes and strategic thinking. You must navigate through each city, destroying everything in your path while avoiding obstacles and enemy creatures. Power-ups are scattered throughout the cities, giving your character an advantage over your enemies. The boss battles at the end of each city are intense and challenging, requiring you to use all your skills and abilities to emerge victorious.