Gameplay-wise, Mario Paint is all about creativity and experimentation. Players can use the SNES Mouse to create simple pictures, paint over black and white images, or free draw their own masterpieces. The game also features a musical composition tool, allowing users to create their own songs using pre-selected notes and themes. Additionally, players can craft greeting cards, animations, and even engage in a fun game of "Gnat Attack", where they must swat flies using the mouse-controlled swatter.