Mary-Kate and Ashley Girls Night Out is a Game Boy Advance game where two friends have planned a girls' night out filled with fashionable clothes and dance moves. To get into the club, players must choose the right outfit from the twins' wardrobe.
The goal of Girls Night Out is to repeat key-press patterns in time with the music, which unlocks new dance moves, songs, and clothes. Players can also become a DJ by creating and saving their own music mixes from techno, house, and disco clips.